When an enzyme isn’t just an enzyme anymore

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When an enzyme isn’t just an enzyme anymore

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To build an enzyme

T he structural com ponents th a t lead to enzyme function are discussed for one simple enzyme-catalysed reac tio n : tha t m ediated by triosephosphate isomerase. First, the recognition and binding of the substrates’ phospho group is seen to involve four m ain-chain —N H — hydrogen bonds, two of which are positioned a t the positive end of a short a-helix aimed precisely at the phospho group a...

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To build an enzyme....

The structural components that lead to enzyme function are discussed for one simple enzyme-catalysed reaction: that mediated by triosephosphate isomerase. First, the recognition and binding of the substrates' phospho group is seen to involve four main-chain-NH-hydrogen bonds, two of which are positioned at the positive end of a short alpha-helix aimed precisely at the phospho group and interact...

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ژورنال

عنوان ژورنال: Journal of Experimental Botany

سال: 2017

ISSN: 0022-0957,1460-2431

DOI: 10.1093/jxb/erx080